Chitosan/porous reduced graphene oxide as active hybrid material for the electrochemical detection of ciprofloxacin

is an antibiotic used to treat a number of bacterial infections [1]. This includes bone and joint infections, intra-abdominal infections, certain type of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections [2,3]. In this study, a new matrix based on a chitosan-porous reduced graphene oxide hybrid (CS-prGO) was prepared and characterized. Modification of a glassy carbon electrode (GCE) with CS-prGO (CS-prGO/GCE) using drop casting allowed for the selective analysis of ciprofloxacin with a limit of detection of 45 nM with a linear range between 0.1-100 μM by differential pulse voltammetry (DPV). In addition, the analytical performance of the proposed sensor was successfully conducted for the determination of ciprofloxacin in real samples, making CS-prGO/GCE electrodes promising interfaces for bio-electrochemical applications.