Synthesis of HKUST-1 and studies of its drug release applications

The metal- organic frameworks (MOFs) are porous crystalline compounds that their structure, connect the metal centers with organic ligands and create a three-dimensional structure. These frameworks are synthesized in a variety of ways under specific temperature and pressure conditions that including hydro (solvo) thermal method, microwave and ultrasonic methods, electrochemical synthesis, diffusion method, solvent evaporation and ionothermal synthesis. In recent years, large numbers of MOFs have shown various potential applications including gas adsorption, sensors, carriers of drugs, Catalyst, separations and etc [1]. In this research, we study the use of drug carrier by MOFs, in which synthesized the metal- organic framework (Cu3 (BTC)2), HKUST-1, with the central metal copper and connector (BTC = 1,3,5-benzenetricarboxylate) and used as a carrier of drugs. This MOF is stable and has a high surface area. HKUST-1 was synthesized by solvothermal method and characterized by (FT- IR) Spectroscopy and X-ray diffraction (XRD), then HKUST-1 was used as drug carrier and the accuracy of drug absorption was evaluated by (FT-IR) spectroscopy and X-ray diffraction (XRD) and thermogravimetry analysis (TGA) spectra.release of drug from HKUST-1 were investigated in PBS (pH = 7) at 37 oC. To do this, at certain intervals, we take our samples and record UV spectra to obtain the degree of release of the drug in a PBS solution at different time. UV spectra showed ergotamine has a slower release than acetaminophen [2].