An expedient one-pot process for synthesis of 3,4-dihydropyrimidin-2-ones via synthesized ZnMn2O4 nanoparticles as catalyst

Dihydropyrimidinones (DHPMs) are important substructures present in a wide variety of biologically active natural products [1]. On the other hand, One-pot multicomponent condensation reactions represent an efficient tool to perform efficient synthesis, because they allow the assembly of complex molecules with maximum simplicity and brevity [2]. The use of natural gel is generating interest of researchers toward cost-effective, nontoxic, economic viability and eco-friendly green synthesis of nanoparticles [3]. In this work, ZnMn2O4 NPs were synthesized using tragacanth gum as biotemplate and Metals nitrate as the metal source by the sol-gel method without using any organic chemicals. Henceforth, ZnMn2O4 nanoparticles as an efficient catalyst were used for the synthesis of 3,4-dihydropyrimidin-2-ones derivatives via solvent free multi-component reactions (Scheme 1). Simple work-up, mild reaction conditions, short reaction times, use of an economically convenient catalyst, and excellent product yields are the advantageous features of this method. The molecular structure of products has been determined by IR, 1HNMR, and 13CNMR techniques