An efficient and green one-pot synthesis of 6-Amino-5cyano-4-phenyl-2-mercapto pyrimidine via three-component reaction of aldehyde، malononitrile and urea using CoAl2O4 nanoparticles as catalyst

Heterocyclic molecules are of biological interest due to their potential physical and chemical properties. Among these the pyrimidine compounds occupy a unique position in pharmaceutical chemistry, as they are components of nucleic acids. The important pyrimidine compounds have diverse applications as bactericidal, fungicidal, analgesics, anti-inflammatory and anti-tumor agents [1,2]. Nowadays, the one step methods involving three component condensation using different reagents and catalysts are popular in synthetic organic chemistry for the synthesis of heterocyclic compounds. These single step methods are more convenient as compared with two step strategies as they require shorter reaction times, product isolation easy and give higher yields and recoveries of the product [3]. As part of our interest in the synthesis of heterocyclic compounds and green chemistry, we report a simple mild and high efficient procedure for one pot three component synthesis of 6-Amino-5cyano-4-phenyl-2-mercapto pyrimidine derivatives. The reaction was performed in ethanol using aryl aldehyde، malononitrile and urea in the presence of CoAl2O4 NPs as a green high efficient catalyst (Scheme 1). Operational simplicity, use of readily available and safe reagents, easy work-up and high yields are some of the positive attributes of this method.