Microwave-assisted multicomponent reaction for the synthesis of 2-amino-4H-chromene derivatives by Ni0.5Co0.5Fe2O4 nanoparticles as a magnetic catalyst under solvent-free conditions

Multi-component metal oxides in comparison with simple metal oxides have the crystal structures and merits of tuning chemical compositions. This specification also enables multi-component metal oxides to show various unique properties such as giant dielectric or catalytic activities and superconductivity [1,2]. Ni0.5Co0.5Fe2O4 has potential applications in high temperature integrated circuits, spintronic, chemical catalysts, high power electronic devices and photocatalysts [3,4]. 2-Aminochromenes are the main components of many naturally occurring products and have been considered in recent years due to useful biological and pharmacological aspects, such as spasmolytic, anticoagulants, diuretic, anticancer, insecticide and antianaphylactin activity [5]. In this study, synthesis of Ni0.5Co0.5Fe2O4 nanoparticles (NPs) was performed by the sol–gel method. The sample was characterized by Fourier transform infrared spectrophotometer (FTIR), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The catalytic activity of Ni0.5Co0.5Fe2O4 NPs has been evaluated for the synthesis of 2-Amino-4H-Chromenes derivatives through three-component under conditions Microwave irradiation and solvent free. The final product was investigated by 1HNMR and 13CNMR spectroscopy. Advantageous features of this study, including green, easy and inexpensive synthesis of nanoparticles, use of microwave irradiation in conditions solvent free, short reaction times, Simple work-up, mild reaction conditions.