Synthesis of 3,4-dihydropyrimidinones (thiones), 1,8-dioxo-octahydroacridines and 1,8-dioxo-octahydroxanthenes as heterocyclic compounds using Ti-MOF nanocatalyst

In this Study, Ti-MOF (Metal organic framework) has been used as a novel, an excellent, stable, recyclable, highly porous hybrid material with large surface area and highly efficient catalyst for one-pot synthesis of some heterocyclic compounds such as dihydropyrimidinones and dihydropyrimidinthiones as Biginelli compounds, octahydroquinazolinone, pyrimido[4,5-d] pyrimidine and tetrahydropyrimidine derivatives as biginelli-like products, 1-amidoalkyl-2-naphtol, 1-aminoalkyl-2-naphtol, acridines, tetrahydrobenzoxanthene-11-one, dioctahydroxanthene and dibenzoxanthene derivatives under solvent-free conditions. The Ti-MOF catalyst was characterized by FT-IR, X-ray diffraction (XRD), Scanning electron microscopy (SEM), energy dispersive X-ray analyzer (EDAX). The structure of the synthetic products identified by spectroscopic methods and the physical properties such FTIR , melting point and 1H-NMR. The main advantage of these reactions compared to the previous reported results involves shorter reaction time, lower amount of catalyst, simple procedure, lower temperature, easy workup, reusability of the catalyst and the products are obtained in high yield.