NiFe2O4@SiO2@amino glucose magnetic nanoparticle as a new, green, effective and magnetically seperable catalyst for the synthesis of benzoimidazo[1,2-a]pyrimidine

Imidazopyrimidines are important scaffolds in medicinal chemistry, as they exhibit a broad spectrum of biological activity such as anticancer, antitubercular, antiviral, antimicrobial, antifungal , anti-inflammatory, Parasiticidal activity, calcium channel blockers, benzodiazepine receptor agonists, and potent P38 MAP kinase inhibitors [1]. Nanoparticles due to their high surface area, high activity and selectivity, easy separation and isolation of products from the reaction mixture have been developed as suitable replacements for conventional heterogeneous catalysts [2]. Besides, using magnetic nanoparticles as catalysts is associated with other advantages including easy synthesis and functionalization, low toxicity and low cost. However, magnetic nanoparticles can easily aggregate into larger clusters because of their anisotropic dipolar attraction. In continuation of our works, to synthesize heterocyclic and biologically active compounds [3], hererin, we wish to report our trial for the synthesize benzoimidazo[1,2-a]pyrimidine using three component synthesis of aldehyde, indanedione and 2-aminoimidazol using NiFe2O4@SiO2@amino glucose magnetic nanoparticle under solvent free condition.