Hydrogel as an efficient catalyst for the synthesis of polyhydroquinoline derivatives under eco-friendly conditions

Polyhydroquinolines are one of the most important classes of heterocyclic scaffolds providing major ligands for biological receptors. Polyhydroquinolines the source of some valuable drugs which are very important in pharmacy. For instance, they demonstrate activity for the treatment of angina pectoris and hypertension [1,2]. The aim of the present work was to search simple and green method for the preparation of polyhydroquinoline derivatives. Poly (2-acrylamido-2-methyl-1-propansulfonic acid) (p(AMPS)) hydrogel [3,4] is used as an efficient heterogeneous catalyst for the synthesis of polyhydroquinoline analogues in high yields via eco-friendly simple reaction method. The catalyst is reusable and can be applied several times without any excessive reduction in of its activity. This new protocol for has significant advantages such as green synthesis, high yields of the products, easy isolation and reusability of the catalyst and free of formation of any hazardous by products.