Vitamin B12: a new catalytic system for the one-pot three-component synthesis of 2,3-dihydroquinazolin-4(1H)-one, 4H-pyrimidobenzothiazole and 2-aminobenzothiazolomethylnaphthol derivatives

For the first time vitamin B12 was applied as a catalyst for the one-pot three-component synthesis of 2,3-dihydroquinazolin-4 (1H) -one, 4H-pyrimidobenzothiazole and 2-aminobenzothiazolomethylnaphthol derivatives from the condensation between aryl aldehydes and 2-aminobenzothiazole with isatoic anhydride or β-naphthol or ethylacetoacetate. The use of catalytic amount of vitamin B12 with high yields is the most advantages of this research. The other advantages are: use of natural and biodegradable catalyst, easy work-up, short reaction times and neat reaction conditions.