Self-assembly Controllable Synthesis of Au Nanoparticles in Liposome by Microwave Method and Investigation its Application for Degradation of MB

Abstract: New drug delivery methods Nano-carriers have been introduced to various types, properties and applications, with nanosensomes being the focus of many researchers and pharmaceutical companies[1]. Gold nanoparticles (GNPs) are well known as an effective material for biomedical applications in the field of drug delivery, biomedical imaging, cancer therapy, and chemical sensing [2]. Liposomes are non‑ionic surfactant vesicles that used as drug carriers for hydrophobic and hydrophilic drugs, imaging in vivo and biological application. Encapsulation is a technology in which target compounds are coated with wall compounds to form microcapsules. This work reports a new chemical processing wet method for precipitation encapsulation of Au nanoparticles within niposomes structures by microwave method. Liposomes were prepared by the lipid film hydration technique [3]. The mixtures of non-ionic surfactant (Span-60) and cholesterol were dissolved in 10 ml distilled water in a round bottomed flask UV–Vis spectrum shows a broad band around 523 nm .The band gap of the Au nanoparticles on liposomal stractures is calculated on the basis of the formulae as given below: Eg = 1240 / λ (eV) As shown in this figure the band gap of Au NPs was 2.37 eV. The electronic and chemical structure, surface compositions, optical properties and morphologies of the prepared Au nanoparticles on liposomal stractures were well characterized using SEM, TEM, FTIR, XRD, EDX as well as nitrogen absorption and desorption. Subsequently, the photocatalytic activity and stability of Au nanoparticles on liposomal stractures were evaluated by the degradation of methylene blue dye under the visible light irradiation, revealing that the composites exhibit enhanced photocatalytic activity compared to pure Au nanoparticles. SEM images of the Au nanoparticles in niosomes synthezied by precipitation method is showen in Fig. 1 The morphology of this sample is spherical-like round of liposome;