شماره ركورد كنفرانس :
3936
عنوان مقاله :
Solubility,modeling and thermodynamic properties of budesonide in ethanol – water mixtures from T = (293.2 to 313.2) K
عنوان به زبان ديگر :
Solubility,modeling and thermodynamic properties of budesonide in ethanol – water mixtures from T = (293.2 to 313.2) K
پديدآورندگان :
Mohammadian Esmail e.mohamadyan1390@gmail.com Tabriz University of Medical Sciences , Rahimpour Elaheh e.mohamadyan1390@gmail.com Tabriz University of Medical Sciences , Fleming Martinez ajouyban@hotmail.com Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia , Jouyban Abolghasem ajouyban@hotmail.com Tabriz University of Medical Sciences
كليدواژه :
محلوليت , بودزونايد , مخلوط حلال دوتايي , مدل جويبان آكري
عنوان كنفرانس :
چهارمين كنفرانس بين المللي پژوهش هاي كاربردي در علوم شيمي و زيست شناسي
چكيده فارسي :
The solubility of budesonide (BDS) in binary mixtures of ethanol and water at 293.2, 298.2, 303.2, 308.2 and 313.2 K was obtained. The trained versions of the van’t Hoff equation, its combined version with log-linear model, Jouyban–Acree model and a combination of van’t Hoff + Jouyban–Acree model were reported to simulate BDS solubility in the binary mixture compositions at various temperatures. The mean relative deviations (MRDs) were used as an accuracy criterion. The MRDs for fitting the solubility data of BDS in binary mixtures of ethanol + water are 6.6 % and 6.5 %, respectively. Some of apparent thermodynamic quantities such as, dissolution enthalpy, dissolution entropy, and Gibbs free energy change of dissolution process of BDS in all the mixed solvents were calculated according to van’t Hoff and Gibbs equations and correlated with the Jouyban- Acree model.
