Bioinformatics assessment OF hsa-mir-3157-5Prelated to single nucleotide polymorphism (rs2213181) OF KIT gene in breast cancer

Bioinformatics assessment OF hsa-mir-3157-5Prelated to single nucleotide polymorphism (rs2213181) OF KIT gene in breast cancer

Breast cancer is the most common cancer in the world and the second is the cause of death in women. Breast Cancer is a type of cancer that originates from breast tissue and is caused by an abnormal growth of the breast in the breast. MicroRNAs (miRNAs) are small (20–22 nucleotides) noncoding RNA molecules that bind to partially complementary mRNA sequences, resulting in target degradation or translation inhibition.1 A growing pool of evidence suggests that miRNA-related gain- or loss-of-function mutations can cause the development and/or progression of cancer Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene. Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit. Studies conducted on NCBI sites indicate that one of the genes involved in this disease is the KIT gene In this study, the hsa-miR-3157-5P analysis of the most relevant signaling pathways for hsa-miR-3157-5P in breast cancer was performed in miRBase, mirwalk2،DAVID databases, respectively. interactions between target and microRNA were derived based on the UTR binding zone of miRwalk2 site, whose related paths were evaluated based on the KEGG database. According to the predictions made by these databases, the most relevant pathways for hsa-miR-3157-5P in breast cancer, Pathway in cancer and Apoptosis.