بررسي اندازه و پتانسيل ζ نانوحامل هاي PLGA - Cs با هدف افزايش كار آمدي داروهاي ضد سرطان

A Review of the Size and ζ Potential of Nano-Carriers PLGA-Cs with the Aim of Increasing the Effectiveness of Anti-Cancer Drugs

Cancer is a major cause of death with more than 10 million annual patients. It is possible that this number reaches 15 million patients per year by 2020. Though chemotherapy has largely been successful in controlling and treating cancer, live tissue damage, systemic toxicity and side effects in this method are among the issues that cannot be overlooked. In order to reduce the negative effects of anticancer drugs on normal tissues, we need to design Nano-sized carriers that can pass the safety barriers and body tissues and reach their target site. In this paper, the size and zeta potential of Nano-carriers PLGA-Cs-Paclitaxel were evaluated. Chitosan connection in physical or conjugated forms may lead to a significant increase of polydispersity. According to the study carried out on the concentration of Chitosan and the type of absorption, it was concluded that nanoparticles size increases with higher concentrations of Chitosan. The zeta potential will increase, provided the conjugation of Chitosan is higher than physical adsorption.

Cancer is a major cause of death with more than 10 million annual patients. It is possible that this number reaches 15 million patients per year by 2020. Though chemotherapy has largely been successful in controlling and treating cancer, live tissue damage, systemic toxicity and side effects in this method are among the issues that cannot be overlooked. In order to reduce the negative effects of anticancer drugs on normal tissues, we need to design Nano-sized carriers that can pass the safety barriers and body tissues and reach their target site. In this paper, the size and zeta potential of Nano-carriers PLGA-Cs-Paclitaxel were evaluated. Chitosan connection in physical or conjugated forms may lead to a significant increase of polydispersity. According to the study carried out on the concentration of Chitosan and the type of absorption, it was concluded that nanoparticles size increases with higher concentrations of Chitosan. The zeta potential will increase, provided the conjugation of Chitosan is higher than physical adsorption.