چكيده فارسي :
The knowledge of physicochemical properties of third generation of ionic liquids, active pharmaceutical ingredients ionic liquid (API-IL), in the presence of amino acids are attractive and essential for various applications in biological activities including efficacy, penetration and rapid solubility of drugs. In this work, density of choline salicylate ([Chol][Sal]) as API-IL in (0.1, 0.2, and 0.3) mol·kg−1 aqueous amino acids (L-alanine and L-arginine ) solutions have been measured at room temperature. Standard partial molar volumes, , have been calculated from measured data. The calculated parameters have been used to interpret the present interactions between [Chol][Sal] and amino acids which are essentially dependent on the structure of amino acids and contribution of the charged end groups and the length of alkyl chain. Results indicate the presence of strong ion-polar interactions between [Chol][Sal] and L-alanine. The amount of this interaction has been decreased for another amino acid L-arginine.
