پديدآورندگان :
Hamtak Maryam Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P.O. Box 1993891176, Tehran, Iran , Fotouhi Lida lfotouhi@alzahra.ac.ir Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P.O. Box 1993891176, Tehran, Iran; , Hosseini Morteza mhosseini@khayam.ut.ac.ir Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran; , Seyed Dorraji Parisa Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P.O. Box 1993891176, Tehran
كليدواژه :
Acyclovir , Multi , walled carbon nanotubes , Nanoporous structure , Glassy carbon , TiO2 nanoparticles.
چكيده فارسي :
In the present study, a new sensor was designed by casting of multi-walled carbon nanotubes (MWCNTs) and TiO2 nanoparticles (TiO2 NPs) into the polymeric matrix, which polymerized in the nanoporous glassy carbon electrode. The performance of the electrode was demonstrated by applying it to the analytical determination of acyclovir concentration. The oxidation of acyclovir has a better result on the modified electrode because of the synergistic effect of nanoporous structure glassy carbon electrode and polymeric film and MWCNTs+TiO2 NPs. Under the optimized conditions the oxidative peak currents increased linearly with the concentration of acyclovir in the range from 0.03 to 1.0 μmol dm-3 with a detection limit of 0.01 μmol dm-3. The measurement of acyclovir concentrations in human fluid and tablet samples demonstrated electrode applicability.
