Determination of Ibuprofen, Aspirin and Venlafaxine by stir bar sorptive extraction coated with Nano absorbent

The present work proposes the application of bar adsorptive microextraction coated with Nano absorbent, combined with liquid desorption followed by gas chromatography-mass spectrometry for the determination of trace levels of three typical drugs (Ibuprofen, Aspirin and Venlafaxine) in urine samples[1]. Assays performed on 25 mL of urine samples spiked at the 1 and 10 μg/L level, yielded average recoveries between 90 and 107% for all drugs under study using optimized experimental conditions. The proposed analytical methodology demonstrated suitable detection limits (0.2 μg/L) and good linear dynamic ranges (1–1400 μg/L) with determination coefficients higher than 0.997. By using the standard addition methodology, the present analytical approach was applied on urine samples, where good selectivity and sensitivity were achieved. The proposed method, which operated under the floating sampling technology, proved to be a suitable sorption-based static microextraction alternative for monitoring trace levels of mentioned drugs in urine samples[2]. The methodology showed to be easy to implement, demonstrating good reproducibility and robustness, allowing the possibility to choose the most selective sorbent, or mixed sorbent phases, according to the compounds of interest.