Modification of magnetic graphene oxide nanohybrid surface with β-Cyclodextrin: Synthesis, characterization, and application as doxorubicin carrier

Although chemotherapy is a common technique for the treating cancer, it has some drawbacks. Side effects of chemotherapy agents for normal cells, insufficient dosages for cancer cells killing and nonspecific drug delivery are some examples of these disadvantages [1]. Recently, drug carriers based on nanomaterial have attracted much attention in the biomedical applications due to the efficient loading, controlled release and targeted delivery of drugs [2-4]. Between the nanoparticles, magnetic graphene oxide (MG) nanohybrid could be a suitable system for drug delivery since it has both superparamagnetic properties and high surface area. In this work, magnetite nanoparticles precipitated on the graphene oxide surface using inverse coprecipitation method. In the next step, obtained MG modified with 3-chloropropyltriethoxysilane and MGSi-Cl was achieved. Finally, as a result of aminated β-cyclodextrin reaction with MGSi-Cl, MG surface was modified (β-CD-MG). Prepared nanocomposite was characterized using Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The Doxorubicin (Dox) loading efficiency for the nanocomposite was obtained ∼37.4%. Dox release results showed that the β-CD-MG has a better performance in the cancer cells conditions compare to normal cells conditions.