Facil preparation of stimuli-responsive graphene oxide/polymer brush nanocomposites as drug delivery agent

Graphene oxide (GO) as a nanosheet with the high surface area has a two-dimensional structure which carbon atoms bonding together in the honeycomb lattice and oxygen-containing functional groups are attached to it [1,2]. Due to its unique physicochemical properties, in the recent years, GO-based nanocomposites attracted a lot of attention in the nanomedicine such as drug delivery, antibacterial system designing and etc [3,4]. For improving graphene dispersity, numerous researchers have focused on the modification of GO with compounds that are appropriate for the medical application. In this work, Go surface was modified with acrylic acid (AA) and N-isopropylacrylamide (NIPAM) via facil and eco-friendly radical polymerization. Polymerization of AA and NIPAM on the GO surface results stimuli-responsive graphene oxide/polymer brush nanocomposite. Nanocomposite was characterized with Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and Scanning electron microscopy (SEM). Amount of grafted polymers was calculated from the thermogravimetric (TGA) curves. Prepared nanocomposite showed the good performance in doxorubicin load and releases.