شماره ركورد كنفرانس :
3550
عنوان مقاله :
Synthesis of Chitosan-based hydrogels and investigation of its capability for loading and releasing of electroactive Methylene Blue (MB) indicator
پديدآورندگان :
Aghaziyarati Farahani Fatemeh Electroanalytical chemistry laboratory, Department of Analytical chemistry, faculty of chemistry, university of Tabriz, Iran , Alipour Esmaeel esmaeel313@gmail.com Electroanalytical chemistry laboratory, Department of Analytical chemistry, faculty of chemistry, university of Tabriz, Iran; , Amini-Fazl Mohammad Sadegh ms.amini@tabrizu.ac.ir Department of Applied chemistry laboratory, , faculty of chemistry, university of Tabriz, Tabriz, Iran; , Mohammadi Reza r.mohammadi@tabrizu.ac.ir Polymer Research laboratory, Department of Organic and Biochemistry, faculty of chemistry, university of Tabriz, Tabriz, Iran;
كليدواژه :
Hydrogel , release , load , methylene blue , electroactive , indicator , chitosan , acrylic acid , glutaraldehyde , Methylene Bis Acrylamide
عنوان كنفرانس :
بيست و پنجمين سمينار ملي شيمي تجزيه انجمن شيمي ايران
چكيده فارسي :
Hydrogels are three dimensional insoluble networks in the water that have cross-links and swell in contact with water. Nowadays, hydrogels are used in various fields due to their variety of structures. These compounds have tendency to absorb water due to the presence of hydrophilic groups such as -SO3H, -CONH2, and -CONH. Gels can be hydrated in a variety of proportions, which in some cases it reach more than 90 percent by weight of polymer, it can be due to the nature of the aqueous medium and the polymer structure [1]. Medications or electrophobic species are trapped in the pores in the structure of the hydrogels and released from their structure based on a mechanism that depends on the spreading coefficient of the drug or the electroactive species [2].Hydrogel-based drug delivery systems are divided into two major groups: 1. Systems with time control. 2. Release systems due to the presence of a stimulus. Environmentally sensitive hydrogels, known as smart systems, are divided into three sub-branches: 1. Release system with physical stimulation such as temperature, electrical current, light and pressure. 2. Release system with chemical stimulation such as pH, the composition of solvents, ions, and special interactions that lead to identify the molecules. 3. Release systems with other stimuli [3].Chitosan-based hydrogels were synthesized and utilized in this study. Then, the amount of hydrogel absorption of water in distilled water and solutions with different pHs, as well as the release of electroactive substance methylene blue (MB) was investigated by these hydrogels at pH 1-12. For this purpose, the hydrogel nanocomposite was synthesized by glutaraldehyde and Methylene Bis Acrylamide in acidic environments (hydrogels have been synthesized separately). Their structure and features were confirmed by XRD, SEM, FTIR devices. Their swelling rate in distilled water was measured and in solutions with different pH (1 to 12), which the highest swelling rate was observed at pH = 1. Electroactive methylene blue was loaded inside the hydrogel nanocomposites and the methylene blue amount released from the hydrogels was measured by electrochemical method and using Autolab instrument.
