Square Wave Voltammetric Determination of Methamphetamine using Glassy Carbon Electrode Modified with Nanoceria Decorated Reduced Graphene Oxide

Methamphetamine (METH), a potent central nervous system stimulant, is the second most widely abused drug in the world [1]. Based on its chemical structure, it can be an electroactive species. However, its oxidation on the electrode surfaces is not facile. In this work, considering the structure of the METH, cerium oxide (called nanoceria; CeO2 NPs) decorated on reduced graphene oxide (rGO) [2,3] was used as electrode modifier to study the redox behavior of METH. A suitable amount of CeO2 on rGO showed a synergistic electrocatalytic effect for optimizing the METH signal. On the modified electrode surface, enhancing of the oxidation peak of METH in cyclic voltammogram compare to bare electrode was observed at 0.6 V potential, in phosphate buffer 0.01 M, pH 10, and scan rate of 0.07 V/s, Square wave voltammetry (SWV) technique was then used as determination method. Different experimental parameters were optimized to achieve the maximum response. Under the optimized experimental conditions, the lowest linear dynamic range and limit of detection for the proposed electrode were obtained 16 µM to 33 µM and 4 µM, respectively. Analysis of METH in real sample showed no significant interference from the matrixes.