Fabrication a new modified electrochemical sensor based on GO/AgCo dendritic nanoparticles, [PMIM] Br ionic liquid for anticancer drug, imatinib determination

Imatinib, is a specific inhibitor of the BCR-ABL tyrosine kinase, platelet-derived growth factor receptors, and the receptor kinase c-KIT. This drug has made progress in chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST) treatment [1]. A novel electrochemical sensor was fabricated for determination of anticancer drug, imatinib (IMA). First GO/AgCo nanoparticles with dendritic morphology were synthesized by a facile method and then the nanocomposite of GO/AgCo and [PMIM] Br ionic liquid was prepared to modify a penciel graphite electrode [2]. The formation of GO/AgCo was characterized using transmission electron microscopy (TEM) and energy dispersion spectroscopy (EDS). The surface morphology of the modified electrode was characterized by scanning electron microscopy (SEM). Electrochemical methods including cyclic voltammetry (CV) and square wave voltammetry (SWV) were used to study the electrochemical behavior of IMA. The effect of several relevant operating parameters was investigated and they were optimized. Under the optimized experimental conditions, the calibration curve was linear within the concentration ranges of 0.05 μM to 60 μM of IMA with a limit of detection (LOD) of 0.015 μM. The proposed sensor was successfully employed for the direct determination of IMA in urine sample.