شماره ركورد كنفرانس :
3550
عنوان مقاله :
Simultaneous Electroanalysis of Tricyclic Anti-depressant drugs (TCAs) using Nanocomposite Electrode based on Copper Molibdate Nanoplates in Mesoporous Carbon
پديدآورندگان :
Habibi-Kool-Gheshlaghi Mona Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran , Faridbod Farnoush faridbodf@khayam.ut.ac.ir Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran; , Karami Mosammam Mahya Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
كليدواژه :
Tricyclic Psychotropic drugs , Tricyclic antidepressant drugs , TCAs , Imipramine(IMP) , Carbamazepine(CBZ) , Nanomaterials , Electroanalytical methods , Differential pulse voltammetry(DPV) , Sensors , Electrode Modification
عنوان كنفرانس :
بيست و پنجمين سمينار ملي شيمي تجزيه انجمن شيمي ايران
چكيده فارسي :
This paper describes a novel, simple, reliable and sensitive electroanalytical procedure proposal for the determination of both effective antipsychotic drugs with low redox activity and poor hydrophilicity imipramine (IMP) and carbamazepine (CBZ) in human plasma sample.[1] In this work, we demonstrated the synthesis and applications of nanocomposite electrode based on CuMoO4 nanoplates-Mesoporous Carbon (CuMoO4/Meso) for electrochemical determination of TCAs CuMoO4 nanoplates was synthesized through sedimentary method.[2] The characterization of the synthesized CuMoO4 nanoplates was accomplished by utilizing FT-IR, FESEM, XRD, EDX and Zeta-potential technique, also the characterization of modified electrodes accomplished by FESEM, EDX and EIS. Modification of the working electrode showed an excellent electrocatalytic oxidation activity toward TCAs at less positive potential with increased current intensity. Differential pulse voltammetry technique was used to carry out electrochemical determinations. The influence of parameters like scan rate, pH (aqueous acid, neutral, and alkaline conditions), amount of the modifiers and concentration on the peak current of the drug were studied. The results showed a well-defined oxidation peak of IMP and CBZ with potential of 0.83 V (instead of 0.88) and 1.09 V (instead of 1.15) vs. Ag/AgCl/3M Cl−, in 0.1 M acetate buffer solution (pH 5.0) as supporting electrolyte, respectively. The obtained negatively charged modified electrode showed fast and sensitive current response to IMP over a wide dynamic linear range of 0.10-100.0 μM (r2 = 0.9933) and 0.5 μM-100.0 μM for CBZ (r2 = 0.9953), with detection limit of 0.030 μM for IMP and 0.089 μM for CBZ (S/N=3) revealing the high-sensitivity properties, respectively. Reproducibility, long life-time (durability) and multiple reusability of the electrode besides its detection limits and wide dynamic linear ranges, are the main advantages of the proposed sensor in comparison with previously reported ones.[3-5] Finally, the proposed method was successfully applied for the determination of IMP and CBZ in biological species.
