A Highly Sensitive Electrochemical Determination of Eletriptan at β-Cyclodextrin and Graphene Oxide Nanosheets Modified Glassy Carbon Electrode

Eletriptan (ELT) is a novel, orally active, selective serotonin 5-HT1B/1D receptor agonist and is second generation antimigraine drug [1]. Eletriptan is used for the treatment of acute migraine headaches. Its pharmacological effects include the constriction of cerebral blood vessels and neuropeptides secretion blockade which eventually relieves the pain [2, 3]. This paper reports a sensitive and selective ELT sensor was developed by utilizing poly (β-cyclodextrin) (β-CD)/ Graphene Oxide Nanosheets (GONs) composite. The composite material was characterized using scanning electron microscopy. The functionalization of GONS with β-CD was scrutinized by varying the content of the β-CD material. Interestingly, the synergistic electrocatalytic activity was examined at different β-CD loadings functionalized GONs in the sensitivity for the detection of ELT. The process of oxidation and its kinetics were established by using cyclic voltammetry, chronoamperometry and differential pulse voltammetry (DPV) techniques. The electrochemical response is adsorption controlled and irreversible in nature involving one electron accompanied by a transfer of one proton. Under the best experimental conditions, the sensor exhibited a linear response to ELT from 0.1 μM to 63 μM, with a limit of detection of 36 nM, one of the lowest achieved up until now. The reproducibility, repeatability and stability of the sensor were examined and are superior to those reported in the literature using similar architectures for ELT sensors. The proposed method was successfully applied for determination of the ELT in human blood serum and urine sample with a good selectivity and suitable recovery.