Modified glassy carbon Electrode as a sensitive voltammetric sensor Based on Chromium metal-organic framework for codeine detection

In the past decade, the important role of metal-organic frameworks in implementing various applications such as sensing has been considerable. Hence, in this study, by introducing a metal-organic framework, we tried to improve and modify electrode to determine and increase their performance and efficiency in detection codeine compound. Cr (III) based metal-organic framework (MIL-101) were prepared via hydrothermal pathway without any surfactants The nano structure and morphology of the synthesized MOF were characterized by Field Emission Scanning Electron Microscopy (FE-SEM), powder X-ray diffraction, thermo gravimetric analysis (TGA), elemental analysis and FTIR spectroscopy. Moreover, Voltammetric determination of nano particle has been studied. Chromium MOF shows high selectivity for sensing of alkaloid compound such as codeine. In this investigation, a glassy carbon electrode (GCE) was used to determination of analgesic effect of codeine [2,3], using a MOF-MIL101 (Cr)-NH2 nano tube as a sensor and one-step electrochemical synthesis in a sodium acetate environment. Therefore, Codeine showed an anodic peak in terms of optimum conditions using GCE at pH 8. The oxidation process was irreversible and controlled by the diffusion process in the applied pH range.The calibration curve performed using a differential pulse voltammetry technique for measuring codeine was linear in the concentration range of 30 μM to 600 μM. Hence, we design a simple and boosted detection strategy for sensing Codeine with limit of detection 10 μM.