Selectivity Evaluation of Methadone Solid Phase Extraction by Molecular Imprinted Polyurethane Foam

A spectrophotometric method by molecular imprinted polyurethane foam as solid phase extraction was studied for selective extraction of methadone in different complex matrixes [1,2]. It was aimed to prepare a foam structure as a selective adsorbent with high capacity, easy to access, low price, and biodegradable. In the first step the imprinted polyurethane foam synthesized. In order to access to high recovery optimization of pH, elution solvent, solvent volume, time, concentration and temperature was done [3]. Effective parameters for raising selectivity of polyurethane were evaluated and characterized. MIP Characterization by SEM and FTIR spectroscopy confirmed the discussion. Thus the outcome of this study will prepare an applicable MIP as selective adsorbent of methadone from complex matrixes such as biological, pharmaceutical and chemical samples with 32% more selectivity than NIP, due to its active sites in the polymer structure.