Preparation of modified carbon-ceramic electrode, based on ionic liquid and Pd nanoparticles supported on porous silicon and its application for simultaneous electrochemical determination of some pharmaceutical compounds

Pd nanoparticles were supported on the surface of porous silicon (PSi) powder by a simple in-situ redox reaction between Pd+2 and PSi, in hydrofluoric acid solution. Pd/PSi nanocomposite as a new electro catalyst is used in modified carbon ionic liquid electrode and has synergetic effect on the oxidation of acetaminophen and mefenamic acid. Several techniques were applied to study of morphological, chemical and electrochemical properties of the prepared nanostructure were distinguished using X-ray diffraction spectroscopy, energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), cyclic voltammetry (CV).The high electrochemical activity, fast electron transfer rate, high surface area and good antifouling properties of this nanostructure enhanced the oxidation peak currents and reduced the peak potentials of ACT and MFA at the surface of the proposed sensor. Simultaneous determination of ACT and MFA was carried out using differential pulse voltammetry (DPV). A linear range of 0.1–30 µmol L-1 was achieved for ACT and MFA with detection limits of 32 nM and 37 nM, respectively. Finally, the prepared electrochemical was applied to determination of ACT and MFA in real samples such as blood serum and pharmaceutical compounds with proper results.