Study of design parameters for a hypothesized dual-drug-eluting stent

فاقد چكيده فارسي

Thrombosis and restenosis are two main issues following stent insertion. The first one is due to blood coagulation which is usually lead to death and the latter is the body response to damages of artery walls after the stent is inserted. In recent generations of drug-eluting stents, anti-proliferative drugs such as Everolimus or Paclitaxel are released to inhibit tissue growth and reduce the risk of restenosis. In order to avoid thrombus formation, some anti-platelet drugs like Aspirin or Clopidogrel are orally being administered after surgery. However, the first dose of anti-platelet drug is delayed for several hours since there is high risk of bleeding at incision sites. This time lag may cause thrombus formation. It seems using drug-eluting stents by which the anti-platelet drug is released into blood to prevent local platelet coagulation in early hours after surgery may surmount this problem. In this study a mathematical model of such hypothesized dual-drug-eluting stent is presented to obtain the release profile of drugs in the lumen and wall of the artery. Furthermore, the effects of different parameters such as pulsatile flow of blood, polymer porosity, and polymer diffusion coefficient on drug release profile are studied in order to achieve the optimal design for the suggested stents.