Author/Authors
A. Provost and G. Bastin، نويسنده ,
DocumentNumber
1384612
Title Of Article
Dynamic metabolic modelling under the balanced growth condition
شماره ركورد
11513
Latin Abstract
The issue of bioprocess dynamical modelling is addressed in the situation where measurements of extracellular species are the
only available data besides measurements of the biomass itself. This question is investigated under the assumption that a metabolic
network connecting the extracellular species is available. A metabolic flux analysis is first performed in order to test the consistency
of the metabolic network. The elementary flux modes are computed and translated into a set of macro-reactions connecting the
extracellular substrates and products. Then a dynamical model, compatible with the underlying metabolic network, is build on the
basis of these macro-reactions. The approach is illustrated with the example of CHO cells cultivated in stirred flasks on a serum-free
medium.
From Page
717
NaturalLanguageKeyword
Metabolic modelling , Metabolic flux analysis , CHO cells , Elementary flux modes
JournalTitle
Studia Iranica
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