Author/Authors :
N.V. Mantzaris and
P. Daoutidis، نويسنده ,
Title Of Article :
Cell population balance modeling
and control in continuous
bioreactors
Latin Abstract :
In this work we address the problem of controlling different moments of the cell mass distribution using cell population balance
modeling for the derivation of appropriate nonlinear feedback control laws. The mathematical model used for dynamic simulation
and controller synthesis consists of a partial integro-differential equation describing the dynamics of the cell mass distribution and
an ordinary integro-differential equation accounting for substrate consumption. Nonlinear feedback laws that induce a desired
closed-loop response for the biomass concentration (first moment), the cell density (zeroth moment) and the second moment of the
cell mass distribution are developed and their performance and robustness to parameter uncertainties are tested via numerical
simulations.
NaturalLanguageKeyword :
Cell mass distribution , Feedback , nonlinear control , Cell population balance models , Robustness
JournalTitle :
Studia Iranica
