Akbolat, Nezahat Dicle University Hospital - Department of Microbiology, Turkey , Yıldız, Abdulnasır Dicle University - Faculty of Sciences - Biology Deparlment, Turkey , Temel, Hamdi Dicle University - Faculty of Education - Chemistry Department, Turkey , İlhan, Salih Siirt University - Faculty of Artand Sciences - Chemistry Department, Turkey , Gül, Kadri Dicle University Hospital - Department of Microbiology, Turkey

Antifungal Studies of Some Metal Complexes with Schiff Base Ligands

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In this study, Nickel (II) and Copper (II) complexes of HL were synthesized. HL denotes the Schiff base ligand which derived from 1-naphtylamine and 2-hydroxynaphthalene-l-carbaldehyde while the H2L represents the other ligand derived from l,2-bis-(p-aminophenoxy)ethane and 2-hydroxynaphthalene-lcarbaldehyde with its Copper(II), Nickel(II), Cobalt(II) and Zinc(II) complexes. The effects of metal complexes with HL and H2L on the development of M. canis, M.gipsium and C. albicans species were investigated. The mild doses such as 0.6, 1.2, 2.4 μg of HL were added into 100 mL sarbose-agar. Then the results were evaluated that M. canis and M. gipsium spores could be germinated whereas in the case of increasing the dose amounts, the diameters of mycelle were decreased. For the both species; spore germination was inhibited at 4.8/100 mL pg dose. However, it s the point to emphasize that a significant decrease was observed in the number of colonies at 0.6 and 1.2 μg/100 mL doses for C. albicans. There were not any novelties between the effects of different complexes of HL and H2L on the development of the three species (P 0.05).

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Words: Schiff base , transition metal complexes , antifungal activities

dicle university journal of institute of natural and applied science

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