مرکز منطقه ای اطلاع رساني علوم و فناوري - Tc-99m MIBI myocard perfusion SPECT findings in patients with typical chest pain and normal coronary arteries

Abstract :

Aim: The aim of this study was to determine the regional distribution of myocardial perfusion abnormalities and defect size using Tc-99m MIBI myocardial perfusion scintigraphy (MPS) in patients with anginal chest pain, positive exercise test and angiographically normal coronary arteries.Material and Methods: Eighty-one (81) patients (40 male, 41 female) who have angina pectoris, positive stress ECG and normal coronary angiography were included this study. Clinical data of these patients who underwent Tc-99m MIBI MPS were retrospectively reviewed. For MPS imaging, the two-day stress-rest Tc-99m MIBI protocol was used.SPECT data were evaluated both visually and semi-quantitatively. The number of abnormal segments was defined as the defect number (DN).Results: There were 65 (80.3%) patients with abnormal MPS and all of these perfusion abnormalities were reversible defects. Frequency of smoking, hyperlipidemia and diabetes mellitus was significantly higher in patients with abnormal MPS than normal MPS. The proportion of postmenopausal women was also higher in the MPS positive group. Most of the myocardial perfusion defects were seen on the nferior wall in both male and female patients on MPS images. The difference between the mean values of DN in the diabetic and nondiabetic groups was statistically significant (5.66±3.14 and 4.51±2.90 respectively. p=0.041).Conclusion: A high prevalence of myocardial perfusion defects was observed in our patients with syndrome X. All of these perfusion abnormalities were reversible. We conclude that the presence of perfusion defects on MPS is a significant objective indicator in patients with cardiac syndrome X.