مرکز منطقه ای اطلاع رساني علوم و فناوري

Abstract :

Although aging is unavoidable, its course can be influenced by various factors. The different organs age in different ways. Starting from the age of 60, people begin to develop neocortical plaques and limbic neurofibrillary tangles independent of development of dementia. Collection of neurofibrillary tangles in limbic system and spreading to neocortex seems to be the pathological correlate of the spectrum of normal aging-mild cognitive impairmentprogressive dementia. Age-related atrophy of the motor cortical regions and corpus callosum may precipitate or coincide with motor declines such as balance and gait deficits, coordination deficits, and movement slowing.Neuroimaging studies have revealed selective changes in the aging brain that reflect neural decline as well as compensatory neural recruitment. Age-associated changes in brain tissue measurements in healthy adults have also been the subject of great interest in recent years, because the determination of normal age-specific values in brain have a role in the evaluation of both clinical-pathologic conditions and normal aging processes. The quantitative information from the analyses has shown that age-related brain tissue loss may vary greatly among different brain regions and between the hemispheres. Physical exercise and dietary measures are currently the only known ways of slowing the aging process.