Uyanıkgil, Y Ege University - Tip Fakültesi - Histoloji ve Embriyoloji, Turkey , Türkkozan, N Y İstanbul Üniversitesi - Diş Hekimliği Fakültesi - Fizyoloji, Turkey , Balcıoğlu, H A İstanbul Üniversitesi - Diş Hekimliği Fakültesi - Anatomi, Turkey , Ateş, U Ege Üniversitesi - Tıp Fakültesi - Histoloji ve Embriyoloji Anabilim Dalı, Turkey , Özel, S Istanbul University - Tip Fakültesi - Biyoistatistik, Turkey

The effects of ovariectomy on the submandibular gland in young female adult rats

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Aim: The salivary gland is one of the target tissues of estrogen. The aim of the study was to investigate the effects of ovariectomy on the stimulated salivary flow rate and morphology of the submandibular gland in sexually mature young rats.Material and Methods: 72 Female Wistar albino rats of 15 weeks of age were used in this study. Submandibular ducts were cannulated intraorally with polyethylene tubes and stimulated salivary flow rates were determined at 1st, 2nd, 4th, 8th, 12th and 16th weeks after the ovariectomy. Histological sections of the submandibular glands were stained and assessed under a light microscope. The diameters of the acinar cells and parenchyma/stroma ratio were calculated using a software system.Results: The stimulated submandibular flow rate was found to be significantly decreased at 1st, 2nd, 4th, 8th, 12th and 16th weeks after the ovariectomy. A decrease in the parenchymal structures and acinar cells, an increase in the interstitial connective tissue and fatty degeneration of the gland were observed.Conclusion: Ovariectomy leads to a decrease in stimulated submandibular salivary flow rate. The changes in gland morphology may be responsible for the decrease in salivary flow rate in young adult rats.

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ovariectomy , stimulated saliva , rat submandibular gland

Ege Journal Of Medicine

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