Akçay, Y Ege Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya Anabilim Dalı, Turkey , Öztürk, G Ege Üniversitesi - Tıp Fakültesi - Dermatoloji Anabilim Dalı, Turkey , Gündüz, K Celal Bayar Üniversitesi - Tıp Fakültesi - Dermatoloji Anabilim Dalı, Turkey , Sözmen, E Ege Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya Anabilim Dalı, Turkey

Paraoxonase activities and erythrocyte TBARS levels in patients with Behçet’s disease and recurrent aphthous stomatitis

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Aim: The aim of our study is to evaluate paraoxonase (PON1), superoxide dismutase (SOD) and catalase (CAT) activities which is antioxidant enzymes, and tiobarbituric acid substance (TBARS) levels, one of the end products of lipid peroxidation induced by reactive oxygen species, in patients with Behçet’s disease (BD) and Recurrent Aphthous Stomatitis. We also aimed to investigate if paraoxonase phenotyping at position 192., may prone to affect to prone to Behcet’s disease and Recurrent Aphthous Stomatitis or not.Materials and Methods: Eryrocyte SOD, CAT activities and TBARS levels, serum PON1 activities were measured by using spectrophotometer. Individuals were classified for PON1 phenotype using the antimode of histogram of PON1 as proposed by Eckerson.Results: Erytrocyte TBARS levels and SOD activities of Behcet’s disease group higher than controls (p=0.05). While TBARS levels depleted in patients under treatment with colchicines, no effect was observed on the antioxidant enzyme activities by colchicine treatment in Behcet’s disease patients (n=10). We also investigated if paraoxonase phenotyping affected to prone to Behcet’s disease. While 18% of patients with Behcet’s disease had BB phenotype, 13,6% of controls. Conclusion: Although our data can not exactly indicate that B allele carriers are more prone to BD and/or any chronic inflammatory disease, taking into account this preliminary study with limited number of cases, we can propose that B allele carriers may have a tendency for these diseases, and further population studies on this allele frequency related with these diseases are needed.

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Paraoxonase , Behçet’s Disease , Recurrent Aphthous Stomatitis , superoxide dismutase , catalase

Ege Journal Of Medicine

97