Author/Authors :
Şen Türk, N Pamukkale Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Zümrütbaş, A E Pamukkale Üniversitesi - Tıp Fakültesi - Üroloji Anabilim Dalı, Turkey , Acar, C Pamukkale Üniversitesi - Tıp Fakültesi - Üroloji Anabilim Dalı, Turkey , Aybek, Z Pamukkale Üniversitesi - Tıp Fakültesi - Üroloji Anabilim Dalı, Turkey
Abstract :
The 2008 World Health Organization classification of urothelial neoplasms recommends the term sarcomatoid carcinoma for all biphasic malignant neoplasms of the urinary tract. A 77-year-old man presented with left flank pain. A computed tomography showed a left hydroureteronephrosis and a suspicous filling defect in the left ureter. A left nephroureterectomy specimen showed a well circumscribed polypoid mass with smooth surfaces that had obliterated the proximal ureter. The mass measured 2 cm in diameter along a poximal 2.5 cm section of the ureter. The cut surface of the tumor was yellowish-white. A histopathological examination of the polypoid mass showed that the tumor had a malignant epithelial component as well as a sarcomatous component. The malignant epithelial component was comprised of a high-grade invasive urothelial carcinoma and adenocarcinoma. The sarcomatous component contained numerous atypical spindle cells with a high mitotic activity. The case was reported as sarcomatoid carcinoma, pT2. It is important for correct and quick diagnosis for urologists to be aware of this rare aggressive neoplasm and also for pathologists to take into account sarcomatoid carcinomas in the differential diagnosis of biphasic tumors of the ureter.
