Author/Authors :
Çetintaş, V B Ege Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Avcı, Ç B Ege Üniversitesi Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Süslüer, S Y Ege Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Eroğlu, Z Ege Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Gündüz, C Ege Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey
Abstract :
Global DNA hypomethylation associates with hyperhomocysteinemia, MTHFR c.677C T homozygosity and the development of cancer.Aim: The aim of this study was to investigate the relationship of the MTHFR c.677C T polymorphism with the risk of cancer in the Turkish population via meta-analysis. Materials and Methods: Studies were identified by searching electronic literature, focusing on the key words; Turkish population, MTHFR C677T and the risk of cancer. All data were analyzed using STATA software. Odds ratio (OR) and 95% confidence interval (Cl) values were calculated using the Mantel-Haentzel statistic according to fixed-effect model.Results: Odds ratio values for Recessive (CC+CT vs TT), Homozygous (CC vs TT) and Dominant (CC vs CT+TT) genetic models were calculated as 1.24 (95% CI: 1.013-1.524), 1.14 (95% CI: 0.93-1.41) and 0.97 (95% CI: 0.869-1.090), respectively. The risk of cancer increased significantly in the TT genotype (p=0.043). Conclusion: Our results support the finding that MTHFR c.677C T polymorphism is a potential biomarker for cancer risk in the Turkish population.
NaturalLanguageKeyword :
MTHFR c.677C T , polymorphism , cancer , meta , analysis
