مرکز منطقه ای اطلاع رساني علوم و فناوري - Antibiotic susceptibility of Pseudomonas aeruginosa strains isolated in a secondary care hospital

Abstract :

Aim: Infections of Pseudomonas aeruginosa in hospitals have high morbidity and mortality rates. The aim of this study is to determine the antimicrobial susceptibility profiles of Pseudomonas aeruginosa strains isolated in Polatlı Duatepe State Hospital between March 2008 and March 2011.Materials and Methods: The strains were isolated and identified by conventional methods and the API 10S (bioMerieux, France) system. Antibiotic susceptibilities were established by disk diffusion and were evaluated according to the Clinical Laboratory Standards Institute (CLSI) criteria.Results: The highest susceptibility rates were found for amikacin, tobramycin and piperacillin/tazobactam.Conclusion: Routine quality control studies for antibiotic susceptibility tests and close observation of suspicious results, is mandatory for each laboratory, in order to achieve good quality performance. Since rates of resistance to antibiotics vary between different centers, it is essential to determine the susceptibility rates of bacteria in order to guide empirical treatment. The results of this study will help the establishment of more appropriate treatment protocols against Pseudomonas aeruginosa infections and will aid in preventing the development of a high number of resistant strains.