Tuncel, Ş Foça Devlet Hastanesi - Ortopedi ve Travmatoloji Kliniği, Turkey , Ozan, F Karaman Devlet Hastanesi - Ortopedi ve Travmatoloji Kliniği, Turkey , Aydın, F Özel Neoks Hiperbarik Oksijen Tedavi Merkezi - Sualtı Hekimliği ve Hiperbarik Tıp, Turkey , Yıldız, H Ege Üniversitesi - Mühendislik Fakültesi - Makine Mühendisliği Bölümü, Turkey , Bora, O A İzmir Atatürk Eğitim ve Araştırma Hastanesi, II. - Ortopedi ve Travmatoloji Kliniği, Turkey

The effect of hyperbaric oxygen therapy on improvement of fracture in denervated rat femur

14779

Objective: In this study, the effect of the sciatic nerve defect in rat femurs on the improvement of the fracture, as well as the effect of hyperbaric oxygen therapy (HBO) on the healing of fracture in the presence of a nervous defect was investigated in pooled experimental groups.Materials and Methods: Twenty-one Wistar albino rats were randomized into three groups. In a control group of rats (Group 1) (n=7), a femur fracture was formed and intramedullary fixation was applied. In Group 2, (n=7) the sciatic nerve defect in rats was formed after a femur fracture and intramedullary fixation was performed In Group 3 (n=7) HBO therapy was administered in rats after a femur fracture, intramedullary fixation and sciatic nerve defect were formed. At the end of four weeks the callus areas of fractured femurs were measured and examined through biomechanical test method.Results: The mean of the callus strength in group 3 was higher than in group 2 and a statistically significant difference was found between them (p 0.05). The mean of the callus area in group 2 was lower than in group 1, therefore this difference was statistically significant (p 0.05). Although the mean values of stiffness, elasticity module, energy storing capacity, twisting moment and bending moment in the broken bones of group 1 were higher than in the broken bones of group 2, a statistically significant difference was found among them in terms of mean values of stiffness, twisting moment and bending moment (p 0.05).Conclusion: Nerve injury causes formation of mechanically nondurable and weak callus in a fracture. Nerve injury with HBO therapy, including its mechanical features, has a negative effect on improvement of the fracture.

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Biomechanics , denervation , hyperbaric oxygen therapy , axial loading , rats , fracture healing

Ege Journal Of Medicine

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