Author/Authors :
Pala, H G Erata Kadın Hastalıkları ve Doğum - Perinatoloji Merkezi, Turkey , Erbaş, O Ege Üniversitesi - Tıp Fakültesi - Fizyoloji Anabilim Dalı, Turkey , Oltulu, F Ege Üniversitesi - Tıp Fakültesi - Histoloji ve Embriyoloji Anabilim Dalı, Turkey , Pala, E E Tepecik Eğitim ve Araştırma Hastanesi - Tıbbi Patoloji Bölümü, Turkey , Aktuğ, H Tepecik Eğitim ve Araştırma Hastanesi - Tıbbi Patoloji Bölümü, Turkey , Yavaşoğlu, A Ege Üniversitesi - Tıp Fakültesi - Histoloji ve Embriyoloji Anabilim Dalı, Turkey
Abstract :
Aim: To investigate glucose toxicity for ovarian damage severity and the effect of these by NF-kappa B way in rat models.Materials and Methods: An experimental diabetes mellitus model was created in seven rats. All seven rats, whose blood glucose levels were normal, were included in the control group. After eight weeks; bilateral oophorectomy was performed and the ovaries were researched histologically. The group characteristics were compared by one-way ANOVA and Mann Whitney U test. p values less than 0.05 were accepted as significant.Results: There was a significant increase of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappa B immune-expression in diabetic rats’ ovary when compared to the control group of normal rats (p=0,0001).Conclusion: Our study shows that glucose toxicity occured severely in the ovaries and this injury originated in the NF-kappa B way in diabetes mellitus. Therefore, NF-kappa B inhibitors continue to be promising in preventing diabetic related tissue injury.
NaturalLanguageKeyword :
Diabetes mellitus , premature ovarian failure , advanced glication end products , receptor of advanced glication end products , NF , kappa B
