Author/Authors :
Turaçlı, İrem Doğan Ufuk Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Ekmekçi, Abdullah Gazi Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey
Abstract :
Sox2 protein is a transcription factor which is important for the maintenance and regulation of the permanence of undifferentiated embryonic and adult stem cells. Like the other pluripotency factors, Sox2 can be regulated by post-transcriptional and post-translational modifications which affect its binding ability to DNA. Sox2 involves in many cellular events in the initiation and progression of tumorigenesis such as proliferation of cancer cells, invasion, migration, metastasis, maintenance of stem like state of cancer stem cells, cellular programming, apoptosis and chemoresistance. Although there is a confliction, it is generally accepted Sox2 is an anti-apoptotic factor in cancer cells. In this review, we discuss the roles of Sox2 in the presence of cell stemness, differantiation and signal transduction. Also, we underline its multifunctionality with discussing Sox2 gaining oncogenic properties by amplification therefore having the potential to be used as a molecular target
