Author/Authors :
inal, zeynep öztürk konya training and research hospital - clinic of obstetrics and gynecology, Turkey , gergerlioğlu, nursadan konya training and research hospital - clinic of pathology, Turkey , küçükosmanoğlu, ilknur konya training and research hospital - clinic of pathology, Turkey , karanis, meryem ilkay konya training and research hospital - clinic of pathology, Turkey
Abstract :
Androgen insensitivity syndrome, previously referred to as testicular feminization syndrome, is an X-linked recessive disorder that is characterized by a mutation in the q11-q12 region of the X chromosome, which results in a deformed androgen receptor gene. Patients with androgen insensitivity syndrome may develop testicular tumors, especially seminomas after puberty. A 35- year-old female patient presented with the complaint of primary amenorrhea and had masses of approximately 4 cm size palpated in the bilateral inguinal regions. The masses were excised and the histopathological examination was reported as bilateral Sertoli cell adenoma. Although the risk of bilateral gonadal tumor development is low in patients with androgen insensitivity syndrome, such malignancies should not be disregarded.
