Karahan, Nermin Süleyman Demirel Üniversitesi - Tip Fakültesi - Patoloji AD, Turkey , Başpınar, Şirin Egirdir Kemik Eklem Hastaliklari Tedavi ve Rehabilitasyon Hastanesi - Patoloji Bölümü, Turkey , Koşar, Alim Süleyman Demirel Üniversitesi - Tıp Fakültesi - Üroloji AD, Turkey , Bozkurt, Korkut Süleyman Demirel Üniversitesi - Tip Fakültesi - Patoloji AD, Turkey , Saraçoğlu, Halil İ Aydin Devlet Hastanesi - Patoloji Bölümü, Turkey , Kapucuoğlu, Nilgün Süleyman Demirel Üniversitesi - Tip Fakültesi - Patoloji AD, Turkey

CD24 expression in benign prostate hyperplasia low and high grade PIN and prostate adenocarcinoma

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Purpose: CD24 recently identified novel prognostic marker gene that functions as an alternative ligand of P-selectin, an adhesion receptor expressed on activated endothelial cells and platelets. It has been implicated in metastatic tumor progression of various solid tumors. We aimed to investigate CD24 expression in prostate adenocarcinomas, low and high grade prostatic intraepithelial neoplasias (PINs) and benign prostate hyperplasias (BPHs), and to evaluate its relationship with histopathological parameters, and serum PSA level. Material and Methods: We examined immunohistochemically the expression of CD24 protein in 76 prostate adenocarcinomas, 16 low grade PIN, 16 high grade PIN, and 14 BPH and correlated our findings with histopathological parameters, and serum PSA level. Results: While we detected CD24 expression in prostat adenocarcinomas and PIN specimens, there was no expression in benign prostate tissues. CD24 immunoreactivity was detected in 48 (63.2%) out of 76 prostate adenocarcinomas. Expression of CD24 was significantly higher in prostate adenocarcinoma and high grade PIN compared with BPH (p=0,000, p=0,040 ). In prostate adenocarcinomas cytoplasmic CD24 expression was significantly positively correlated with Gleason score (p=0.000, r= 0.465) and PSA level (p=0.022, r=0.263). Conclusions: Our findings demonstrated that positive CD24 expression occurs in prostate adenocarcinomas with high Gleason score, and high PSA level. We suggest that CD24 might constitute an important moleculer marker for prostate cancer.

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Prostate adenocarcinoma , PIN , CD24 , immunohistochemistry

Medical Journal Of Suleyman Demirel University

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