Sulak, Osman Süleyman Demirel Üniversitesi - Tip Fakültesi - Anatomi AD, Turkey , Çankaya, Seyhan Süleyman Demirel Üniversitesi - Tip Fakültesi - Anatomi AD, Turkey , Özgüner, Gülnur Süleyman Demirel Üniversitesi - Tip Fakültesi - Anatomi AD, Turkey , Şahin, Önder Istanbul Üniversitesi - Deneysel Araþtirma Merkezi, Turkey , Songur, Ahmet Afyon Kocatepe Üniversitesi - Tıp Fakültesi - Anatomi Anabilim Dalı, Türkey , Baş, Orhan Rize Üniversitesi - Tıp Fakültesi - Anatomi Anabilim Dalı, Turkey

Gebelik esnasinda diazinon a maruz kalan ratlarin yenidogan yavrularinin akciger dokusunda olusan morfolojik degisiklikler ve bu degigikliklere kafeik asit fenetil ester in etkisinin arastirilmasi

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Objectives: The aim of present study is to investigate morphological changes occurred in lungs of newborn rats whose mothers exposed to diazinon during their pregnancy, and effects of CAPE on these changes. Methods: Thirty female Wistar albino rats were randomly divided into three groups, as follows: Group I(n; 10): control group, Group II (n; 10): 25mg/kg/day diazinon treated group in the 14-18 days of pregnancy, Group III (n; 10): 25 mg/kg/day diazinon + 10 µmol /kg/day CAPE treated group in the 14-18 days of pregnancy. Diazinon administrated by oral gavage in corn oil and CAPE administrated intraperitoneally. Results: In group II, diazinon causes low weight gain in pregnant rats and low birth weights in their newborns. Histopathological examinations of lung tissues revealed intraparenchymal inflammatory infiltration, alveolar and bronchial hemoraji, intraparenchymal vascular congestion and thrombozis and emphysematous changes. In group III, administration of CAPE has considerably reduced these pathological changes. As a result, low weightgain in pregnant rats and low birth weights in their newborns also, histopathological changes in the lung tissues of newborn rats determined. It is also concluded that CAPE has ameliorating effects on these histopathological changes.

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Diazinon , CAPE , histopathology , lung , rat

Medical Journal Of Suleyman Demirel University

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