Ugan, Yunus Süleyman Demirel Üniversitesi - Tıp Fakültesi - Romatoloji BD, Turkey , Ermis, Fatih Isparta Devlet Hastanesi - Gastroenteroloji Bölümü, Turkey , Sahin, Mehmet Süleyman Demirel Üniversitesi - Tıp Fakültesi - Romatoloji BD, Turkey

Familial Mediterranean Fever

15529

Familial Mediterranean fever (FMF) is an autosomal recessively inherited autoinflammatory disease which is characterized with relapsing fever and serositis attacks. It is known that the disease is caused by a mutation in the MEFV gene located on the short arm of chromosome 16. Despite, there are more than 150 identified gene mutations up to date, diagnosis of FMF is still clinically made on the basis of the history of typical attacks. The most important and prognostic complication of the disease is amyloidosis. is the only treatment agent which prevents both the development of amyloidosis and reduces the severity and frequency of FMF attacks. Here, we aimed to review the latest knowledge about this ancient disease.

139

Familial Mediterranean Fever , Fever , Colchicine , Amyloidosis

Medical Journal Of Suleyman Demirel University

143