Çelik, Dilek Asci Süleyman Demirel Üniversitesi - Tip Fakültesi - Tibbi Biyoloji AD, Turkey , Kosar, Pinar Aslan Süleyman Demirel Üniversitesi - Tip Fakültesi - Tibbi Biyoloji AD, Turkey , Özçelik, Nurten Süleyman Demirel Üniversitesi - Tip Fakültesi - Tibbi Biyoloji AD, Turkey

Micro RNAs and their relation with cancer

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MicroRNAs (miRNAs) are a class of small non-coding endogen RNA molecules usually 20-23 nucleotides at length. They have shown to role in many physiological and pathological processes including cell characterization and differentiation. Additionally some miRNAs were identified as oncogenes while some others are tumor-suppressors in cancer. This data indicates their modulatory effects on tumor progression, invasion and metastasis. After the effects of miRNA s on carcinogenesis were discovered, expression levels of miRNAs on different cancer and normal cell lines were evaluated and differences found between normal and pathological tissues. Comparisons of miRNA expression levels between cancer and normal cells have gained attention on diagnosis, prognosis ant treatment of cancer. With the increasing knowledge about miRNA functions and their roles in cancer, they became a new hope for understanding molecular pathology of cancer and for developing molecular targeting treatment method.

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MicroRNA , cancer , oncogene , tumor suppressor gene

Medical Journal Of Suleyman Demirel University

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