Author/Authors :
Devrim, Tuba Burdur Devlet Hastanesi - Department of Pathology, Turkey , Karahan, Nermin Süleyman Demirel University - School of Medicine - Department of Pathology, Turkey , Başpınar, Şirin Süleyman Demirel University - School of Medicine - Department of Pathology, Turkey , Bozkurt, Kemal K. Süleyman Demirel University - School of Medicine - Department of Pathology, Turkey , Koçer, Murat Süleyman Demirel University - School of Medicine - Department of Medical Oncology, Turkey , Kapucuoğlu, Nilgün Acıbadem Hospital - Department of Pathology, Turkey
Abstract :
Background: To investigate the prognostic significance of CD133 expression in colorectal carcinomas (CRC). Material and Method: CD133 expression was investigated immunohistochemically on the paraffin blocks of 70 sporadic colorectal carcinoma cases which were diagnosed at the department of pathology in Suleyman Demirel University. Low positivity was defined as positive immunoreactivity in 50% of neoplastic glands, and high positivity was defined as positive immunoreactivity in ≥ 50% of neoplastic glands. Furthermore, the relation of CD133 immunohistochemical expression with pathologic parameters and survival rates were investigated. Results: CD133 expression was detected in 82.9% of the examined cases and high CD133 expression was significantly associated with poorer disease free survival (p=0.004). CD133 expression was significantly higher in tumors located in rectosigmoidal region (p=0.005) and showed a significant negative correlation with histologic grade (p=0.020). Conclusion: In the present study none of the poorly differentiated tumors showed high CD133 positivity probably due to the lack of luminal areas in poorly differentiated areas of the tumor, which is in consistence with the previously published data. Our results indicate that immunohistochemical CD133 expression, which correlates with poorer disease free survival, may be an independent prognostic marker in colorectal carcinoma. The findings of this study support the cancer stem cell model, and reveal the clinical importance of CD133 in CRC cases and present a strong association between high CD133 expression and disease-free survival.
NaturalLanguageKeyword :
CD133 , colon cancer , immunohistochemistry , prognosis
