Author/Authors
Armağan, İlkay Süleyman Demirel Üniversitesi - Tıp Fakültesi - Histoloji ve Embriyoloji AD, Turkey
Title Of Article
The role doaf moxaidgaet iivne l isvterer sasn idn kmidentheoy toref xraattes- induced÷
شماره ركورد
15647
Abstract
Methotrexate (MTX) is one of the indispensable chemotherapeutic agents for cancer patients. But, MTX induce some adverse effects such as nephrotoxicity and hepatotoxicity. Thus cause dose limitations and terminate the cancer therapy. This will cause decrease in the survival of cancer patients. Hence, we aimed to summarize the MTX’s action mechanism on hepatotoxicity and nephrotoxicity, which of those are most known adverse effects of MTX. However, taking precautions in MTX treatment is crucial in chemotherapy. According to the literatures, reactive oxygen species (ROS) triggered oxidative stress is responsible in MTX-induced hepatotoxicity and nephrotoxicity. Hence, the MTX treatment must be accompanied with antioxidants to protect the patients from those adverse effects.
From Page
151
NaturalLanguageKeyword
Antioxidant , Methotrexate , Oxidative stress , Reactive Oxygen Species
JournalTitle
Medical Journal Of Suleyman Demirel University
To Page
155
JournalTitle
Medical Journal Of Suleyman Demirel University
Link To Document