ŞEN, Serdar Zonguldak Kadın Doğum ve Çocuk Hastalıkları Hastanesi - Kadın Hastalıkları ve Doğum, Türkiye , HIZLI, Deniz Fatih Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum, Türkiye , TAŞÇI, Yasemin Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi - Kadın Hastalıkları ve Doğum, Türkiye , DİLBAZ, Serdar Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi - Kadın Hastalıkları ve Doğum, Türkiye

The Importance of Thrombophilic Factors in Early Pregnancy Losses

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Objective: The aim of the present study was to investigate the role of thrombophilic factors in fetal losses at 10-16 gestational weeks. Materials and Methods: Between April 2003 and May 2004, 50 women who were hospitalized due to fetal loss at 10-16 gestational weeks were defined as study group and 50 women with at least 1 healthy term infant and had no previous miscarriage history were defined as control group. Activated protein C resistance, anti-thrombin III deficiency, protein S deficiency and the presence of anticardiolipin antibodies were evaluated. Chi-square test and independent sample t-test were used for statistical analysis. The cut-off value for statistical significance was set at p 0.05. Results: The groups were similar with regard to mean serum antithrombin III, anticardiolipin antibodies and protein S level. However, activated protein C resistance was more frequent in the study group (22% vs 6%, p=0,047). Moreover, thrombophilia prevelance was higher in study group when compared to control group (42% vs 16%, p=0.001). Conclusion: High prevelance of of thrombophilia found in patients with fetal loss at 10 gestational weeks suggests that thrombophilia screening should be a part of the management of these patients.

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Anticardiolipin antibodies , Thrombophilia , Fetal loss.

Fırat Medical Journal

93