مرکز منطقه ای اطلاع رساني علوم و فناوري - Histomorphological Examination of Age-Related Change in Rat Esophagus and Stomach

Author/Authors :

TAŞLIDERE, Elif İnönü Üniversitesi - Tıp Fakültesi - Histoloji-Embriyoloji Anabilim Dalı, Türkiye , KURUŞ, Meltem İnönü Üniversitesi - Tıp Fakültesi - Histoloji-Embriyoloji Anabilim Dalı, Türkiye , KAZANCI, Alper İnönü Üniversitesi - Tıp Fakültesi - Histoloji-Embriyoloji Anabilim Dalı, Türkiye , OTLU, Ali İnönü Üniversitesi - Tıp Fakültesi - Histoloji-Embriyoloji Anabilim Dalı, Türkiye

Abstract :

Objective: In this study, it was aimed that age-related morphological changes in rat esophagus and stomach was investigated with light microscopy. Materials and Methods: In this study, 21 female Sprage-Dawley rats were used. Rats were divided into three groups as follows. Group1:21 days old, Group2:2 month old and Group3:19 month old. At the end of the examination esophagus and stomach tissues were removed.The sections stained wiht hematoxylin eosin and evaluated light microscopically. Results: The mean thickness of esophagus epithelium was measured. It was 31.85±5.7 μm in Group1, 40.95±6.7 μm in Group2 and 44.68±9.2 μm in Group3. The mean thickness of tunica muscularis in esophagus measured. It was 128.9±23.1 μm in Group 1, 207.8±38,5 μm in Group2 and 256.07±35.52 in Group3. We observed that the thickness of esophagus epithelium and tunica muscularis were significantly increased by age in all groups (p 0.05). Likewise, the mean thickness of tunica mucosa in stomach was measured. It was 67.87±8.25 μm in Group1, 127.76±21.8 μm in Group2 and 181.23±35.1 μm in Group3. The mean thickness of tunika muscularis in stomach was measured. It was 56.65±15.9 μm in Group1, 125.68±21.36μm in Group2, 174.07±22.5 μm in Group3. We observed that the thickness of tunica mucosa and tunica muscularis were significantly increased by age in all groups (p 0.05). Conclusion: The morfology of esophagus and stomach in rats were observed to change with increasing age. We believe that obtained in this study as age related changes in rat esophagus and stomach may shed light on other morphological studies and that will contribute to the literature.