OZKAN, Zehra Sema Firat University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , ATILGAN, Remzi Firat University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , KUMBAK, Banu Firat University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , SIMSEK, Mehmet Firat University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , SAPMAZ, Ekrem Firat University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey

Impact of Gonadotrophin Releasing Hormone Antagonist Duration on In-Vitro Fertilization Outcome

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Objective: To evaluate whether oocyte quality, implantation and pregnancy rates in intra-cytoplasmic sperm injection (ICSI) cycles are related to the duration of gonadotrophin-releasing hormone antagonist (GnRH-ant) use. Material and Method: A total of 138 patients who were treated with GnRH ant protocol at the IVF Clinic from March 2010 to January 2012 were enrolled in this study. The patients were classified into three groups according to duration of GnRH-ant use. Group 1: 4 days (n=51); group 2:5 days (n=57); group 3:6 days (n=30) antagonist application. Main outcome measures were implantation rate, pregnancy rate, fertilization rate, number of oocytes retrieved (NOR), number of mature oocytes (NMO). Results: The NOR and NMO were the lowest in group 1, intermediate in group 2, and the highest in group 3 respectively. There is no statistically significant difference between the groups in regard to total gonadotrophins used, fertilization, implantation or pregnancy rates. The pregnancy rates per ET and cycle were 37.9% and 31.8%, respectively. Conclusion: We noticed that longer GnRH-ant use was associated with more oocytes retrieved and more mature oocytes, but no difference in fertili zation, implantation or pregnancy rates concluding that longer GnRH-ant use does not have a detrimental effect on in vitro fertilization outcome.

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GnRH antagonist duration , Fertilization , Implantation , Pregnancy.

Fırat Medical Journal

154